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Guideline Matrix - Part I

Zebrafish Preclinical Resource

Study TypeAnimal ModelOECD Guideline Name
Acute Toxicity(96 Hours)Adult Zebrafish (Danio rerio)
TG 203
Fish Acute Toxicity Test
Acute Embryo Toxicity(96 Hours Post-Fertilization)Zebrafish Embryos (0–96 hpf)
TG 236
Fish Embryo Acute Toxicity (FET) Test
Early-Life Stage Toxicity(30–60 Days*)Zebrafish (Embryo to Juvenile)
TG 210
Fish Early-Life Stage Toxicity Test
Growth Toxicity(28 Days)Juvenile Zebrafish
TG 215
Fish Juvenile Growth Test
Reproductive Toxicity(21 Days)Sexually Mature Adult Zebrafish
TG 229
Fish Short-Term Reproduction Assay
Endocrine/Reproductive Screening(21 Days)Sexually Mature Adult Zebrafish
TG 230
21-Day Fish Assay
Sexual Development Toxicity(60–90 Days*)Zebrafish (Embryo to Sexual Differentiation Stage)
TG 234
Fish Sexual Development Test
Bioaccumulation Study(Several Weeks to Months)Juvenile or Adult Zebrafish
TG 305
Bioaccumulation in Fish: Aqueous and Dietary Exposure
Guideline Matrix - Part II

Rat and Mice Toxicity Studies

Study TypeAnimal ModelOECD Guideline Name
Acute Oral Toxicity(14 Days Observation)Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse
TG 420
Acute Oral Toxicity – Fixed Dose Procedure
Acute Oral Toxicity(14 Days Observation)Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse
TG 423
Acute Toxic Class Method
Acute Oral Toxicity(14 Days Observation)Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse
TG 425
Acute Oral Toxicity – Up-and-Down Procedure
Acute Dermal Toxicity(14 Days Observation)Wistar Rat, Sprague-Dawley Rat
TG 402
Acute Dermal Toxicity
Acute Inhalation Toxicity(14 Days Observation)Wistar Rat, Sprague-Dawley Rat
TG 403
Acute Inhalation Toxicity
Skin Sensitisation(6 Days)CBA/J Mouse, BALB/c Mouse
TG 429
Local Lymph Node Assay (LLNA)
Sub-acute Toxicity(28 Days)Wistar Rat, Sprague-Dawley Rat
TG 407
Repeated Dose 28-Day Oral Toxicity Study in Rodents
Sub chronic Toxicity(90 Days)Wistar Rat, Sprague-Dawley Rat
TG 408
Repeated Dose 90-Day Oral Toxicity Study in Rodents
Prenatal Developmental Toxicity(Gestation Period)Wistar Rat, Sprague-Dawley Rat, CD-1 Mouse
TG 414
Prenatal Developmental Toxicity Study
Reproductive Toxicity Screening(~6–8 Weeks)Wistar Rat, Sprague-Dawley Rat
TG 421
Reproduction/Developmental Toxicity Screening Test
Combined Repeated Dose & Reproductive Toxicity(~6–8 Weeks)Wistar Rat, Sprague-Dawley Rat
TG 422
Combined Repeated Dose Toxicity Study with Reproduction/Developmental Toxicity Screening Test
Neurotoxicity Study(Protocol Dependent)Wistar Rat, Sprague-Dawley Rat
TG 424
Neurotoxicity Study in Rodents
Chronic Toxicity(≥12 Months)Wistar Rat, Sprague-Dawley Rat
TG 452
Chronic Toxicity Studies
Carcinogenicity(18–24 Months)Sprague-Dawley Rat, Wistar Rat, CD-1 Mouse, Swiss Albino Mouse
TG 451
Carcinogenicity Studies
Chronic Toxicity & Carcinogenicity(Up to 24 Months)Wistar Rat, Sprague-Dawley Rat
TG 453
Combined Chronic Toxicity/Carcinogenicity Studies
Extended One-Generation Reproductive Toxicity(Several Months)Wistar Rat, Sprague-Dawley Rat
TG 443
Extended One-Generation Reproductive Toxicity Study
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OECD-203 fish acute toxicity-testOECD-210 fish early life stage toxicity-testOECD-229 fish short term reproduction assayOECD-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionOECD-234 fish sexual development testOECD-236 fish embryo acute toxicity fet-testOECD-305 bioaccumulation in fish aqueous and dietary exposureOECD-215 fish juvenile growth testOECD-402-acute-dermal-toxicityOECD-403 acute inhalation toxicityOECD-407 repeated dose 28 day oral toxicity study in rodentsOECD-408 repeated dose 90 day oral toxicity study in rodentsOECD-414 prenatal developmental toxicity studyOECD-420 acute oral toxicity fixed dose procedureOECD-421 reproduction developmental toxicity screening testOECD-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testOECD-423 acute oral toxicity acute toxic class-methodOECD-424 neurotoxicity study in rodentsOECD-425 acute oral toxicity up and down procedureOECD-429 skin sensitisation local lymph node assayOECD-443 extended one generation reproductive toxicity studyOECD-451 carcinogenicity studiesOECD-452 chronic toxicity studiesOECD-453 combined chronic toxicity carcinogenicity studiesOECD-203 fish acute toxicity-testOECD-210 fish early life stage toxicity-testOECD-229 fish short term reproduction assayOECD-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionOECD-234 fish sexual development testOECD-236 fish embryo acute toxicity fet-testOECD-305 bioaccumulation in fish aqueous and dietary exposureOECD-215 fish juvenile growth testOECD-402-acute-dermal-toxicityOECD-403 acute inhalation toxicityOECD-407 repeated dose 28 day oral toxicity study in rodentsOECD-408 repeated dose 90 day oral toxicity study in rodentsOECD-414 prenatal developmental toxicity studyOECD-420 acute oral toxicity fixed dose procedureOECD-421 reproduction developmental toxicity screening testOECD-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testOECD-423 acute oral toxicity acute toxic class-methodOECD-424 neurotoxicity study in rodentsOECD-425 acute oral toxicity up and down procedureOECD-429 skin sensitisation local lymph node assayOECD-443 extended one generation reproductive toxicity studyOECD-451 carcinogenicity studiesOECD-452 chronic toxicity studiesOECD-453 combined chronic toxicity carcinogenicity studiesOECD-203 fish acute toxicity-testOECD-210 fish early life stage toxicity-testOECD-229 fish short term reproduction assayOECD-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionOECD-234 fish sexual development testOECD-236 fish embryo acute toxicity fet-testOECD-305 bioaccumulation in fish aqueous and dietary exposureOECD-215 fish juvenile growth testOECD-402-acute-dermal-toxicityOECD-403 acute inhalation toxicityOECD-407 repeated dose 28 day oral toxicity study in rodentsOECD-408 repeated dose 90 day oral toxicity study in rodentsOECD-414 prenatal developmental toxicity studyOECD-420 acute oral toxicity fixed dose procedureOECD-421 reproduction developmental toxicity screening testOECD-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testOECD-423 acute oral toxicity acute toxic class-methodOECD-424 neurotoxicity study in rodentsOECD-425 acute oral toxicity up and down procedureOECD-429 skin sensitisation local lymph node assayOECD-443 extended one generation reproductive toxicity studyOECD-451 carcinogenicity studiesOECD-452 chronic toxicity studiesOECD-453 combined chronic toxicity carcinogenicity studies