Zebrafish Preclinical Resource
| Study Type | Animal Model | OECD Guideline Name |
|---|---|---|
| Acute Toxicity(96 Hours) | Adult Zebrafish (Danio rerio) | TG 203 Fish Acute Toxicity Test |
| Acute Embryo Toxicity(96 Hours Post-Fertilization) | Zebrafish Embryos (0–96 hpf) | TG 236 Fish Embryo Acute Toxicity (FET) Test |
| Early-Life Stage Toxicity(30–60 Days*) | Zebrafish (Embryo to Juvenile) | TG 210 Fish Early-Life Stage Toxicity Test |
| Growth Toxicity(28 Days) | Juvenile Zebrafish | TG 215 Fish Juvenile Growth Test |
| Reproductive Toxicity(21 Days) | Sexually Mature Adult Zebrafish | TG 229 Fish Short-Term Reproduction Assay |
| Endocrine/Reproductive Screening(21 Days) | Sexually Mature Adult Zebrafish | TG 230 21-Day Fish Assay |
| Sexual Development Toxicity(60–90 Days*) | Zebrafish (Embryo to Sexual Differentiation Stage) | TG 234 Fish Sexual Development Test |
| Bioaccumulation Study(Several Weeks to Months) | Juvenile or Adult Zebrafish | TG 305 Bioaccumulation in Fish: Aqueous and Dietary Exposure |
Rat and Mice Toxicity Studies
| Study Type | Animal Model | OECD Guideline Name |
|---|---|---|
| Acute Oral Toxicity(14 Days Observation) | Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse | TG 420 Acute Oral Toxicity – Fixed Dose Procedure |
| Acute Oral Toxicity(14 Days Observation) | Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse | TG 423 Acute Toxic Class Method |
| Acute Oral Toxicity(14 Days Observation) | Wistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse | TG 425 Acute Oral Toxicity – Up-and-Down Procedure |
| Acute Dermal Toxicity(14 Days Observation) | Wistar Rat, Sprague-Dawley Rat | TG 402 Acute Dermal Toxicity |
| Acute Inhalation Toxicity(14 Days Observation) | Wistar Rat, Sprague-Dawley Rat | TG 403 Acute Inhalation Toxicity |
| Skin Sensitisation(6 Days) | CBA/J Mouse, BALB/c Mouse | TG 429 Local Lymph Node Assay (LLNA) |
| Sub-acute Toxicity(28 Days) | Wistar Rat, Sprague-Dawley Rat | TG 407 Repeated Dose 28-Day Oral Toxicity Study in Rodents |
| Sub chronic Toxicity(90 Days) | Wistar Rat, Sprague-Dawley Rat | TG 408 Repeated Dose 90-Day Oral Toxicity Study in Rodents |
| Prenatal Developmental Toxicity(Gestation Period) | Wistar Rat, Sprague-Dawley Rat, CD-1 Mouse | TG 414 Prenatal Developmental Toxicity Study |
| Reproductive Toxicity Screening(~6–8 Weeks) | Wistar Rat, Sprague-Dawley Rat | TG 421 Reproduction/Developmental Toxicity Screening Test |
| Combined Repeated Dose & Reproductive Toxicity(~6–8 Weeks) | Wistar Rat, Sprague-Dawley Rat | TG 422 Combined Repeated Dose Toxicity Study with Reproduction/Developmental Toxicity Screening Test |
| Neurotoxicity Study(Protocol Dependent) | Wistar Rat, Sprague-Dawley Rat | TG 424 Neurotoxicity Study in Rodents |
| Chronic Toxicity(≥12 Months) | Wistar Rat, Sprague-Dawley Rat | TG 452 Chronic Toxicity Studies |
| Carcinogenicity(18–24 Months) | Sprague-Dawley Rat, Wistar Rat, CD-1 Mouse, Swiss Albino Mouse | TG 451 Carcinogenicity Studies |
| Chronic Toxicity & Carcinogenicity(Up to 24 Months) | Wistar Rat, Sprague-Dawley Rat | TG 453 Combined Chronic Toxicity/Carcinogenicity Studies |
| Extended One-Generation Reproductive Toxicity(Several Months) | Wistar Rat, Sprague-Dawley Rat | TG 443 Extended One-Generation Reproductive Toxicity Study |